Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

USP8 Antikörper (C-Term)

This anti-USP8 antibody (ABIN2788008) is a Rabbit Polyclonal antibody detecting USP8 in WB, IHC. Suitable for Human, Mouse, Pig, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio).
Produktnummer ABIN2788008

Kurzübersicht für USP8 Antikörper (C-Term) (ABIN2788008)

Target

Alle USP8 Antikörper anzeigen
USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reaktivität

Human, Maus, Schwein, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt

  • 34
  • 3
  • 1
Kaninchen

Klonalität

  • 35
  • 3
Polyklonal

Konjugat

  • 28
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser USP8 Antikörper ist unkonjugiert

Applikation

  • 35
  • 16
  • 14
  • 8
  • 7
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH LDDFKAAEHA

    Homologie

    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%

    Produktmerkmale

    This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C terminal region of human USP8
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 1118 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    USP8 (Ubiquitin Specific Peptidase 8 (USP8))

    Andere Bezeichnung

    USP8

    Hintergrund

    USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
    Alias Symbols: FLJ34456, HumORF8, KIAA0055, MGC129718, UBPY
    Protein Interaction Partner: VAMP8, LRIG1, TARDBP, UBC, PTEN, STAT6, TSEN2, POLD3, HTT, YWHAB, YWHAQ, YWHAE, EGFR, PTPN23, SRC, ERBB4, UBE2I, UBE2G1, FARSB, VPS4B, TRIM63, TRIM55, PJA1, USP28, TRIM54, USP21, USP15, GRAP2, CHMP4C, CHMP1B, CHMP2A, CHMP2B, RNF41, USP8, SPP1, CHMP1A, NBR
    Protein Size: 1118

    Molekulargewicht

    127 kDa

    Gen-ID

    9101

    NCBI Accession

    NM_005154, NP_005145

    UniProt

    P40818
Sie sind hier:
Chat with us!