FAS Antikörper (N-Term)

Produktnummer ABIN2787943

Der Kaninchen Polyklonal anti-FAS Antikörper (ABIN2787943) detektiert spezifisch FAS in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Schwein und Ziege.

Kurzübersicht für FAS Antikörper (N-Term) (ABIN2787943)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human, Schwein, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FAS Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: FAS Antibody - N-terminal region

Sequenz: GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK

Homologie: Goat: 100%, Human: 100%, Pig: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FAS

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59115-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: FAS

Hintergrund:

Background Information: FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Gene Name: Fas (TNF receptor superfamily, member 6)

Alternative Symbols: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6

Protein Name: Tumor necrosis factor receptor superfamily member 6

Molekulargewicht: 36kDa

Gen-ID: 355

NCBI Accession: NP_000034

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity