FAS Antikörper (N-Term)

Produktnummer ABIN2787943

Dieses Anti-FAS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FAS in WB. Geeignet für Human, Schwein und Ziege.

Kurzübersicht für FAS Antikörper (N-Term) (ABIN2787943)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human, Schwein, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FAS Antikörper

Bindungsspezifität: N-Term

Sequenz: GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK

Homologie: Goat: 100%, Human: 100%, Pig: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FAS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 335 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: FAS

Hintergrund: FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Symbols: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Protein Interaction Partner: FADD, CAV1, FAS, APOA5, TMX1, UBQLN1, MBD4, TP63, TCAP, BAG6, UBC, HNRNPC, GADD45A, CCND3, ATP6V0B, SQSTM1, Ube2i, PRAM1, RARA, PML, DAXX, FASLG, TRADD, MAP3K5, BMX, Traf1, FAF1, FAF2, TRAF3, KRIT1, TNF, BRE, LRIF1, FEM1B, FBF1, FAIM2, CASP8AP2, C14orf1,
Protein Size: 335

Molekulargewicht: 36 kDa

Gen-ID: 355

NCBI Accession: NM_000043, NP_000034

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity