Caspase 10 Antikörper (Middle Region)

Produktnummer ABIN2787909

Der Kaninchen Polyklonal anti-Caspase 10 Antikörper (ABIN2787909) detektiert spezifisch Caspase 10 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Caspase 10 Antikörper (Middle Region) (ABIN2787909)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Caspase 10 Antikörper

Bindungsspezifität: Middle Region

Sequenz: HNNVTKVEME MVLQKQKCNP AHADGDCFVF CILTHGRFGA VYSSDEALIP

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CASP10. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP10

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 479 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Andere Bezeichnung: CASP10

Hintergrund: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ALPS2, FLICE2, MCH4
Protein Interaction Partner: FADD, PRDX6, XIAP, RB1, Dlg4, PHF20L1, OIP5, ECE2, RIOK3, NFKBIL1, CASP8, RNF34, BFAR, CASP8AP2, MSN2, PTC2, AIM9, GLN3, SLT2, GPA1, STE20, ATG13, RPL21B, VPS30, CUP9, TPK2, GAL4, FAR11, WHI3, ATG4, FAR3, FAR8, ITT1, MPH1, SSM4, ASG1, BFR1, ORT1, MBR1, CW
Protein Size: 479

Molekulargewicht: 12 kDa

Gen-ID: 843

NCBI Accession: NM_001230, NP_001221

UniProt: Q92851

Pathways: Apoptose, Caspase Kaskade in der Apoptose