WDR77 Antikörper (N-Term)

Produktnummer ABIN2787792

Dieses Anti-WDR77-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von WDR77 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen und Kaninchen.

Kurzübersicht für WDR77 Antikörper (N-Term) (ABIN2787792)

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WDR77 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-WDR77 Antikörper

Bindungsspezifität: N-Term

Sequenz: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against WDR77. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human WDR77

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 342 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu WDR77

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Andere Bezeichnung: WDR77

Hintergrund: WDR77 is the non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. WDR77 might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Alias Symbols: HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44, MEP-50, p44/Mep50
Protein Interaction Partner: TP53, CUL3, SMAD1, AR, UBC, ASB15, WWOX, ZBTB1, SMYD1, COPS4, COPS7A, DCAF8, COPS8, PRMT5, TBC1D4, EPB41L2, HGS, FBXO6, PAN2, SNRPC, PPP1R8, POLR2C, PCBP2, HNRNPM, GRB2, QKI, TOE1, PPIL1, SAP30BP, LSM3, GPKOW, SF3A1, SF3B4, RBM5, PQBP1, THOC1, AQR, BAG2,
Protein Size: 342

Molekulargewicht: 38 kDa

Gen-ID: 79084

NCBI Accession: NM_024102, NP_077007

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization