GRB2 Antikörper (N-Term)

Produktnummer ABIN2787701

Dieses Anti-GRB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRB2 in WB. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für GRB2 Antikörper (N-Term) (ABIN2787701)

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRB2 Antikörper

Bindungsspezifität: N-Term

Sequenz: AKYDFKATAD DELSFKRGDI LKVLNEECDQ NWYKAELNGK DGFIPKNYIE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GRB2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 217 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GRB2

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Andere Bezeichnung: GRB2

Hintergrund: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Protein Interaction Partner: AES, C1orf94, LNX1, LZTS2, GAREM, ARHGAP9, NIF3L1, HOMEZ, DPPA4, TP53BP2, SHC1, TRIM27, REL, EPS8, HNRNPK, ERBB4, ABI3, ZBTB7B, IKZF3, INCA1, PRR22, PNMA5, STAMBP, DDX17, CBLB, LMO2, LCP2, ABL2, ABL1, NUTM2F, WBP11, GAB2, WASL, UBC, CBL, DNM1, EGFR, ACTG1
Protein Size: 217

Molekulargewicht: 24 kDa

Gen-ID: 2885

NCBI Accession: NM_002086, NP_002077

UniProt: P62993

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation