H2AFX Antikörper (N-Term)

Produktnummer ABIN2787619

Der Kaninchen Polyklonal Anti-H2AFX-Antikörper wurde für WB validiert. Er ist geeignet, H2AFX in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio) und Pferd zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für H2AFX Antikörper (N-Term) (ABIN2787619)

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-H2AFX Antikörper

Bindungsspezifität: N-Term

Sequenz: SGRGKTGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGHYA ERVGAGAPVY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against H2AFX. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human H2AFX

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 143 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-H2AFX Antikörper (ABIN2787619)

Wen, Zhu, Zhang, Keum, Zykova, Yao, Peng, Zheng, Cho, Ma, Bode, Dong: "MST1 promotes apoptosis through phosphorylation of histone H2AX." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39108-16, (2010) (PubMed).

Details zu H2AFX

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Andere Bezeichnung: H2AFX

Hintergrund: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. H2AFX is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: H2A.X, H2A/X, H2AX
Protein Interaction Partner: UBC, HIST1H3A, USP17L2, UBD, RNF8, DDX21, XRCC6, NBN, NCL, HIST1H3B, ESR1, CENPA, TP53BP1, TOPORS, MDC1, BRCA1, ATR, ATM, PRKDC, CBX5, TRIM28, EGFR, BMI1, HIST2H3C, PML, XRCC5, UBB, TERF2, RNF2, SIRT7, CSNK2A1, ARRB2, ARRB1, PAXIP1, MRE11A, ATF2, MCPH1, C
Protein Size: 143

Molekulargewicht: 16 kDa

Gen-ID: 3014

NCBI Accession: NM_002105, NP_002096

UniProt: P16104

Pathways: Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus