RCAN1 Antikörper (N-Term)

Produktnummer ABIN2787429

Der Kaninchen Polyklonal Anti-RCAN1-Antikörper wurde für WB validiert. Er ist geeignet, RCAN1 in Proben von Human, Maus, Ratte und Hund zu detektieren.

Kurzübersicht für RCAN1 Antikörper (N-Term) (ABIN2787429)

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RCAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RCAN1 Antikörper

Bindungsspezifität: N-Term

Sequenz: MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS

Homologie: Dog: 93%, Human: 100%, Mouse: 77%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against RCAN1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RCAN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 252 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RCAN1

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Andere Bezeichnung: RCAN1

Hintergrund: RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Protein Interaction Partner: UBC, PPP3CA, NEDD8, APP, FBXW11, BTRC, FBXW4, TOLLIP, TRAF6, IRAK1, HSP90AA1, STAT2, GSK3B, MAP3K3, MAPK3, UXT,
Protein Size: 252

Molekulargewicht: 28 kDa

Gen-ID: 1827

NCBI Accession: NM_004414, NP_004405

UniProt: P53805

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development