PDE8A Antikörper (C-Term)

Produktnummer ABIN2787372

Der Kaninchen Polyklonal Anti-PDE8A-Antikörper wurde für WB validiert. Er ist geeignet, PDE8A in Proben von Human, Maus, Ratte, Kaninchen, Hund, Pferd, Rind (Kuh), Schwein, Meerschweinchen und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für PDE8A Antikörper (C-Term) (ABIN2787372)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Pferd, Rind (Kuh), Schwein, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDE8A Antikörper

Bindungsspezifität: C-Term

Sequenz: VSNPCRPLQY CIEWAARISE EYFSQTDEEK QQGLPVVMPV FDRNTCSIPK

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE8A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDE8A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 783 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Andere Bezeichnung: PDE8A

Hintergrund: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000). See MIM 171885.
Alias Symbols: FLJ16150, HsT19550
Protein Interaction Partner: UBC,
Protein Size: 783

Molekulargewicht: 88 kDa

Gen-ID: 5151

NCBI Accession: NM_173454, NP_775656

UniProt: O60658

Pathways: cAMP Metabolic Process