PDE8A Antikörper (C-Term)

Produktnummer ABIN2787371

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE8A in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Kaninchen, Hund, Pferd, Rind (Kuh), Meerschweinchen und Zebrafisch (Danio rerio).

Kurzübersicht für PDE8A Antikörper (C-Term) (ABIN2787371)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Pferd, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDE8A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PDE8A Antibody - C-terminal region

Sequenz: SSNPYHNSTH SADVLHATAY FLSKERIKET LDPIDEVAAL IAATIHDVDH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE8A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDE8A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57752-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Andere Bezeichnung: PDE8A

Hintergrund:

Background Information: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000).

Gene Name: Phosphodiesterase 8A

Alternative Symbols: HsT19550

Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Molekulargewicht: 91kDa

Gen-ID: 5151

NCBI Accession: NP_002596

UniProt: O60658

Pathways: cAMP Metabolic Process