PIDD Antikörper (Middle Region)

Produktnummer ABIN2787144

Der Kaninchen Polyklonal anti-PIDD Antikörper wird verwendet zum Nachweis von PIDD in Proben von Human, Maus, Ratte, Meerschweinchen, Rind (Kuh) und Hund. Er wurde validiert für WB.

Kurzübersicht für PIDD Antikörper (Middle Region) (ABIN2787144)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIDD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PIDD Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PIDD1 Antibody - middle region

Sequenz: RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LRDD

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57270-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Andere Bezeichnung: PIDD1

Hintergrund:

Background Information: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Gene Name: p53-induced death domain protein 1

Alternative Symbols: LRDD, PIDD

Protein Name: p53-induced death domain-containing protein 1

Molekulargewicht: 83kDa

Gen-ID: 55367

NCBI Accession: NP_060964

UniProt: Q9HB75

Pathways: p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity