PKC iota Antikörper (Middle Region)

Produktnummer ABIN2786697

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PKC iota in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für PKC iota Antikörper (Middle Region) (ABIN2786697)

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC iota Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PKC iota Antikörper

Bindungsspezifität: Middle Region

Sequenz: TVIPYNPSSH ESLDQVGEEK EAMNTRESGK ASSSLGLQDF DLLRVIGRGS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRKCI. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRKCI

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 596 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PKC iota

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Andere Bezeichnung: PRKCI

Hintergrund: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Alias Symbols: DXS1179E, MGC26534, PKCI, nPKC-iota
Protein Interaction Partner: PARD6B, PARD6A, UBC, AMOT, SQSTM1, CRX, NPM1, IKBKG, YWHAE, IL1RAP, HSP90AA1, GAB1, CASP8, PARD3, APP, UBD, MAP2K5, MARK2, ARHGAP17, TJP1, ELAVL1, CDK7, MBP, TSC22D1, TTR, FABP4, PARD6G, MARK4, CDC37, RAPGEF2, PNMA1, NIPSNAP1, YWHAZ, YWHAH, MYO10, LLGL1,
Protein Size: 596

Molekulargewicht: 68 kDa

Gen-ID: 5584

NCBI Accession: NM_002740, NP_002731

UniProt: P41743

Pathways: Neurotrophin Signalübertragung, Cell-Cell Junction Organization, Tube Formation