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PKC iota Antikörper (N-Term)

PRKCI Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB01026 unconjugated
Produktnummer ABIN391010
  • Target Alle PKC iota (PRKCI) Antikörper anzeigen
    PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 176-207, N-Term
    Reaktivität
    • 51
    • 39
    • 17
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 8
    Kaninchen
    Klonalität
    • 43
    • 8
    Polyklonal
    Konjugat
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PKC iota Antikörper ist unkonjugiert
    Applikation
    • 43
    • 22
    • 19
    • 13
    • 13
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PKC iota antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-207 amino acids from the N-terminal region of human PKC iota.
    Klon
    RB01026
    Isotyp
    Ig Fraction
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  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Lechuga, Baranwal, Ivanov: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).

    Wang, Li, Du, Lu, Zou: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." in: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).

    Li, Wang, Liu, Xiao, Lu, Zou: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).

  • Target
    PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
    Andere Bezeichnung
    PKC iota (PRKCI Produkte)
    Synonyme
    DXS1179E antikoerper, PKCI antikoerper, nPKC-iota antikoerper, aPKC[l] antikoerper, hal antikoerper, has antikoerper, PRKCI antikoerper, PKC antikoerper, 2310021H13Rik antikoerper, AI427505 antikoerper, PKClambda antikoerper, Pkci antikoerper, Pkcl antikoerper, Prkcl antikoerper, aPKClambda antikoerper, mKIAA4165 antikoerper, protein kinase C iota antikoerper, protein kinase C, iota antikoerper, PRKCI antikoerper, prkci antikoerper, Prkci antikoerper
    Hintergrund
    PKC iota belongs to the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehydes-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis.
    Molekulargewicht
    68262
    Gen-ID
    5584
    NCBI Accession
    NP_002731
    UniProt
    P41743
    Pathways
    Neurotrophin Signalübertragung, Cell-Cell Junction Organization, Tube Formation
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