PMS2 Antikörper (Middle Region)

Produktnummer ABIN2786522

Dieses Anti-PMS2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PMS2 in WB. Geeignet für Human, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Hund, Pferd und Saccharomyces cerevisiae.

Kurzübersicht für PMS2 Antikörper (Middle Region) (ABIN2786522)

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Reaktivität: Human, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Hund, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PMS2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA

Homologie: Cow: 85%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%, Yeast: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against PMS2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PMS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 862 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PMS2

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Andere Bezeichnung: PMS2

Hintergrund: PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: UBC, MLH1, PCNA, PMS2P1, NSF, MSH2, LMNA, MSH6, SPRTN, BRIP1, FAN1, CLSPN, TOPBP1, PSD2, MMS19, ATAD3A, NSUN2, UBR5, COPG2, PSD3, COPG1, RUVBL2, EXO1, AIFM1, RUVBL1, XPO1, SMARCA4, RFC2, PSMD5, PSMC6, PSMC3, PSMC2, PSMC1, PRKDC, PPP2CA, PIK3C2A, MSH3, MCM
Protein Size: 862

Molekulargewicht: 96 kDa

Gen-ID: 5395

NCBI Accession: NM_000535, NP_000526

UniProt: P54278

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response