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PRAME Antikörper (N-Term)

PRAME Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2786465
  • Target Alle PRAME Antikörper anzeigen
    PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
    Bindungsspezifität
    • 16
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 43
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein
    Wirt
    • 41
    • 2
    Kaninchen
    Klonalität
    • 43
    Polyklonal
    Konjugat
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRAME Antikörper ist unkonjugiert
    Applikation
    • 21
    • 16
    • 13
    • 13
    • 9
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR
    Homologie
    Cow: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 85%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PRAME. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
    Top Product
    Discover our top product PRAME Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 509 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Liu, Zhao, Lu, Ning, Ma, Diaz, OConnor: "A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle." in: Reproduction (Cambridge, England), Vol. 153, Issue 6, pp. 847-863, (2017) (PubMed).

  • Target
    PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
    Andere Bezeichnung
    PRAME (PRAME Produkte)
    Synonyme
    PRAME antikoerper, CT130 antikoerper, MAPE antikoerper, OIP-4 antikoerper, OIP4 antikoerper, 4930534P07Rik antikoerper, preferentially expressed antigen in melanoma antikoerper, PRAME antikoerper, Prame antikoerper
    Hintergrund
    PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
    Alias Symbols: MAPE, OIP4, CT130
    Protein Interaction Partner: PRAME, RBX1, CUL2, TCEB2, TCEB1, ZNF408, FBXL12, XRN2, HIST4H4, HIST2H2BE, HIST2H2AC, HIST3H3, UBC, RARA, TP53RK, OSGEP, TPRKB, KDM1A, BAG2, LAGE3, UBL4A, SNRPB, RPS13, RPL22, RPL10, RFC4, PSMC4, HNRNPM, HNRNPH1, HNRNPF, HNRNPC, NEDD8, STK19,
    Protein Size: 509
    Molekulargewicht
    56 kDa
    Gen-ID
    23532
    NCBI Accession
    NM_006115, NP_006106
    UniProt
    P78395
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
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