ERCC1 Antikörper (N-Term)

Produktnummer ABIN2786445

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ERCC1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Meerschweinchen und Kaninchen.

Kurzübersicht für ERCC1 Antikörper (N-Term) (ABIN2786445)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ERCC1 Antikörper

Bindungsspezifität: N-Term

Sequenz: TVDTSAQAAP QTYAEYAISQ PLEGAGATCP TGSEPLAGET PNQALKPGAK

Homologie: Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ERCC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human ERCC1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Andere Bezeichnung: ERCC1

Hintergrund: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Alias Symbols: UV20, COFS4, RAD10
Protein Size: 213

Molekulargewicht: 23 kDa

Gen-ID: 2067

NCBI Accession: NM_001166049, NP_001159521

UniProt: P07992

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response