Carabin Antikörper (N-Term)

Produktnummer ABIN2786421

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Carabin in WB. Er zeigt eine Reaktivität gegenüber Human, Rind (Kuh), Ratte, Hund, Meerschweinchen, Pferd und Schwein.

Kurzübersicht für Carabin Antikörper (N-Term) (ABIN2786421)

Target: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Reaktivität: Human, Rind (Kuh), Ratte, Hund, Meerschweinchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Carabin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Carabin Antikörper

Bindungsspezifität: N-Term

Sequenz: MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Pig: 93%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TBC1D10C. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TBC1D10C

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 446 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Carabin

Target: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Andere Bezeichnung: TBC1D10C

Hintergrund: TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).[supplied by OMIM].
Alias Symbols: FLJ00332, MGC46488, EPI64C, CARABIN
Protein Interaction Partner: NOTCH2NL, KRTAP13-1, KLHL12, KRTAP5-9, HOXA1, APP, PPP3R2,
Protein Size: 446

Molekulargewicht: 50 kDa

Gen-ID: 374403

NCBI Accession: NM_198517, NP_940919

UniProt: Q8IV04