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Carabin Antikörper (N-Term)

TBC1D10C Reaktivität: Human, Maus WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990768
  • Target Alle Carabin (TBC1D10C) Antikörper anzeigen
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    AA 100-150, N-Term
    Reaktivität
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 8
    • 1
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 9
    Dieser Carabin Antikörper ist unkonjugiert
    Applikation
    • 9
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Carabin Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Carabin antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Carabin. The immunogen is located within amino acids 100 - 150 of Carabin.
    Isotyp
    IgG
    Top Product
    Discover our top product TBC1D10C Primärantikörper
  • Applikationshinweise
    Carabin antibody can be used for detection of Carabin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Carabin Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    Carabin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Andere Bezeichnung
    Carabin (TBC1D10C Produkte)
    Synonyme
    CARABIN antikoerper, EPI64C antikoerper, 1810062O14Rik antikoerper, AI428527 antikoerper, RGD1311490 antikoerper, TBC1 domain family member 10C antikoerper, TBC1 domain family, member 10c antikoerper, TBC1 domain family, member 10C antikoerper, TBC1D10C antikoerper, Tbc1d10c antikoerper
    Hintergrund
    Carabin Antibody: Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
    Gen-ID
    374403
    NCBI Accession
    NP_940919
    UniProt
    Q8IV04
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