ALKBH3 Antikörper (Middle Region)

Produktnummer ABIN2786204

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch ALKBH3 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Pferd, Kaninchen, Rind (Kuh), Hund, Meerschweinchen und Schwein und wurde in 1 Publikation erwähnt.

Kurzübersicht für ALKBH3 Antikörper (Middle Region) (ABIN2786204)

Target: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Reaktivität: Human, Maus, Ratte, Pferd, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ALKBH3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: EMRKKPPPEE NGDYTYVERV KIPLDHGTLL IMEGATQADW QHRVPKEYHS

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ALKBH3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ALKBH3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 286 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ALKBH3 Antikörper (ABIN2786204)

Sundheim, Vågbø, Bjørås, Sousa, Talstad, Aas, Drabløs, Krokan, Tainer, Slupphaug: "Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage." in: The EMBO journal, Vol. 25, Issue 14, pp. 3389-97, (2006) (PubMed).

Details zu ALKBH3

Target: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Andere Bezeichnung: ALKBH3

Hintergrund: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine.The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1519 AB042029.1 2-1520
Alias Symbols: ABH3, DEPC-1, DEPC1, MGC118790, MGC118792, MGC118793, PCA1
Protein Interaction Partner: AK8, LNX1, GLRX3, IKZF1, GOLGA2, SRPK2, SRPK1,
Protein Size: 286

Molekulargewicht: 33 kDa

Gen-ID: 221120

NCBI Accession: NM_139178, NP_631917

UniProt: Q96Q83

Pathways: DNA Reparatur