GLE1 Antikörper (N-Term)

Produktnummer ABIN2785781

Der Kaninchen Polyklonal Anti-GLE1-Antikörper wurde für WB validiert. Er ist geeignet, GLE1 in Proben von Human, Ratte, Maus, Pferd, Rind (Kuh), Hund, Schwein, Kaninchen, Saccharomyces cerevisiae und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für GLE1 Antikörper (N-Term) (ABIN2785781)

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Reaktivität: Human, Ratte, Maus, Pferd, Rind (Kuh), Hund, Schwein, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GLE1 Antikörper

Bindungsspezifität: N-Term

Sequenz: LKLREAEQQR VKQAEQERLR KEEGQIRLRA LYALQEEMLQ LSQQLDASEQ

Homologie: Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 77%, Rat: 100%, Yeast: 90%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against GLE1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GLE1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 659 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Andere Bezeichnung: GLE1

Hintergrund: GLE1 is a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm.This gene encodes a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: GLE1L, hGLE1, LCCS, LCCS1
Protein Interaction Partner: RNF2, UBC, ELAVL1, NUPL2, NUP155, EIF3F, UXT, KRT10,
Protein Size: 659

Molekulargewicht: 75 kDa

Gen-ID: 2733

NCBI Accession: NM_001499, NP_001490

UniProt: Q53GS7