UBE4B Antikörper (N-Term)
Kurzübersicht für UBE4B Antikörper (N-Term) (ABIN2785770)
Target
Alle UBE4B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- N-Term
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Sequenz
- SPMFCSVASF GASSLSSLYE SSPAPTPSFW SSVPVMGPSL ASPSRAASQL
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Homologie
- Dog: 79%, Human: 100%, Pig: 79%
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Produktmerkmale
- This is a rabbit polyclonal antibody against UBE4B. It was validated on Western Blot using a cell lysate as a positive control.
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Aufreinigung
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human UBE4B
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Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
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Kommentare
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Antigen size: 1302 AA
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- UBE4B (Ubiquitin Conjugation Factor E4 B (UBE4B))
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Andere Bezeichnung
- UBE4B
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Hintergrund
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B is an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. The gene that encodes the protein is also the strongest candidate in the neuroblastoma tumor suppressor genes. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: E4, HDNB1, KIAA0684, UBOX3, UFD2, UFD2A
Protein Interaction Partner: TRIP12, UBC, FBXW11, HGS, STAM, TP53, MDM2, NUSAP1, NUDCD3, RBM12, PDE3A, CDKN2A, UBL7, UBE2D3, CDC27, TTK, IGBP1, HDLBP, TTC9C, MRPL53, ZFYVE19, SARNP, SRPRB, VPS35, UBA6, VPS29, UFM1, SBDS, VPS36, UBQLN1, UBXN7, UBE2C, AHCYL1, SSSCA1, SF3B4, PPIF, SCO2,
Protein Size: 1302 -
Molekulargewicht
- 146 kDa
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Gen-ID
- 10277
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NCBI Accession
- NM_001105562, NP_001099032
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UniProt
- O95155
Target
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