APOE Antikörper (N-Term)

Produktnummer ABIN2785631

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch APOE in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte und Zebrafisch (Danio rerio).

Kurzübersicht für APOE Antikörper (N-Term) (ABIN2785631)

Target: APOE (Apolipoprotein E (APOE))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-APOE Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: APOE Antibody - N-terminal region

Sequenz: LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC

Homologie: Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against APOE. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54284-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu APOE

Target: APOE (Apolipoprotein E (APOE))

Andere Bezeichnung: APOE

Hintergrund:

Background Information: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Gene Name: Apolipoprotein E

Alternative Symbols: AD2, LPG, APO-E, ApoE4, LDLCQ5

Protein Name: Apolipoprotein E

Molekulargewicht: 36 kDa

Gen-ID: 348

NCBI Accession: NP_000032

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism