PIAS2 Antikörper (N-Term)

Produktnummer ABIN2785610

Produktdetails anti-PIAS2 Antikörper

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RELYRRRYPR TLEGLSDLST IKSSVFSLDG GSSPVEPDLA VAGIHSLPST

Homologie: Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 92%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PIAS2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PIAS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 572 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Andere Bezeichnung: PIAS2 (PIAS2 Produkte)

Synonyme: MGC83751 antikoerper, piasx antikoerper, wu:fi05f09 antikoerper, PIAS2 antikoerper, 6330408K17Rik antikoerper, AI462206 antikoerper, ARIP3 antikoerper, AU018068 antikoerper, Dib antikoerper, Miz1 antikoerper, PIASxalpha antikoerper, PIASxb antikoerper, PIASxbeta antikoerper, SIZ2 antikoerper, DIP antikoerper, MIZ antikoerper, MIZ1 antikoerper, PIASX antikoerper, PIASX-ALPHA antikoerper, PIASX-BETA antikoerper, ZMIZ4 antikoerper, protein inhibitor of activated STAT 2 L homeolog antikoerper, protein inhibitor of activated STAT 2 antikoerper, protein inhibitor of activated STAT, 2 antikoerper, pias2.L antikoerper, PIAS2 antikoerper, pias2 antikoerper, Pias2 antikoerper

Hintergrund: Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX
Protein Interaction Partner: HIC1, GOLGA2, GFAP, PHC1, TRIM23, ZBTB8A, SUMO1P1, ACY3, TSR2, NAV2, CCHCR1, CCNDBP1, MAPKAPK2, ZBED1, PIAS2, SUMO1, UBE2I, TP53, PRKAB2, MX2, TRIM63, TRIM55, CTBP1, GTF2I, SUMO2, SUMO3, MYC, DNMT3A, TICAM2, RUFY1, PIAS4, C1QA, ADA, PAXIP1, UBC, PLAGL1, P
Protein Size: 572

Molekulargewicht: 63 kDa

Gen-ID: 9063

NCBI Accession: NM_173206, NP_775298

Pathways: JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling