Inhibin alpha Antikörper (N-Term)

Produktnummer ABIN2785468

Der Kaninchen Polyklonal anti-Inhibin alpha Antikörper (ABIN2785468) detektiert spezifisch Inhibin alpha in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Schwein, Schaf, Kaninchen, Hund, Ziege, Pferd und Saccharomyces cerevisiae.

Kurzübersicht für Inhibin alpha Antikörper (N-Term) (ABIN2785468)

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Schaf, Kaninchen, Hund, Ziege, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Inhibin alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Inhibin alpha Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: INHA Antibody - N-terminal region

Sequenz: GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP

Homologie: Cow: 100%, Dog: 86%, Goat: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 79%, Rat: 93%, Sheep: 100%, Yeast: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against INHA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INHA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP53597-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Andere Bezeichnung: INHA

Hintergrund:

Background Information: INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Inhibin, alpha

Alternative Symbols: -

Protein Name: Inhibin alpha chain

Molekulargewicht: 40 kDa

Gen-ID: 3623

NCBI Accession: NP_002182

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion