IL-24 Antikörper (C-Term)

Produktnummer ABIN2785371

Dieses Anti-IL-24-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL-24 in WB. Geeignet für Human, Ratte, Maus, Hund und Pferd.

Kurzübersicht für IL-24 Antikörper (C-Term) (ABIN2785371)

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Reaktivität: Human, Ratte, Maus, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IL-24 Antikörper

Bindungsspezifität: C-Term

Sequenz: STLANNFVLI VSQLQPSQEN EMFSIRDSAH RRFLLFRRAF KQLDVEAALT

Homologie: Dog: 77%, Horse: 85%, Human: 100%, Mouse: 85%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against IL24. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of IL24

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 207 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IL-24

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Andere Bezeichnung: IL24

Hintergrund: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27 kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: C49A, FISP, IL-24, IL10B, MDA7, Mob-5, ST16, mda-7, MOB5
Protein Interaction Partner: DCD, RARG, CCR5, CLU, UBC, IL20RA,
Protein Size: 207

Molekulargewicht: 22 kDa

Gen-ID: 11009

NCBI Accession: NM_001185156, NP_001172085

UniProt: Q53XZ7

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagie