CISH Antikörper (N-Term)

Produktnummer ABIN2785100

Der Kaninchen Polyklonal anti-CISH Antikörper wird verwendet zum Nachweis von CISH in Proben von Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Hund und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für CISH Antikörper (N-Term) (ABIN2785100)

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CISH Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Cish Antibody - N-terminal region

Sequenz: RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Cish. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52798-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: Cish

Hintergrund:

Background Information: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Name: Cytokine inducible SH2-containing protein

Alternative Symbols: C, CI, Cis, F17, F23, CIS1, SOCS, CIS-1

Protein Name: Cytokine-inducible SH2-containing protein

Molekulargewicht: 28kDa

Gen-ID: 12700

NCBI Accession: NP_034025

UniProt: Q62225

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus