TXNIP Antikörper (C-Term)

Produktnummer ABIN2784817

Der Kaninchen Polyklonal Anti-TXNIP-Antikörper wurde für WB validiert. Er ist geeignet, TXNIP in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Meerschweinchen und Schaf zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für TXNIP Antikörper (C-Term) (ABIN2784817)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TXNIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TXNIP Antikörper

Bindungsspezifität: C-Term

Sequenz: DTPEAPPCYM DVIPEDHRLE SPTTPLLDDM DGSQDSPIFM YAPEFKFMPP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TXNIP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TXNIP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 391 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TXNIP Antikörper (ABIN2784817)

Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6912-7, (2008) (PubMed).

Details zu TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Andere Bezeichnung: TXNIP

Hintergrund: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.
Alias Symbols: EST01027, HHCPA78, THIF, VDUP1
Protein Interaction Partner: UBC, DDIT4, ECD, TXN, TP53, SMURF2, UL49, ITCH, ELAVL1, FHL1, ZBTB32, ZBTB16, SCEL, HDAC1, TXNRD1, KPNA2,
Protein Size: 391

Molekulargewicht: 44 kDa

Gen-ID: 10628

NCBI Accession: NM_006472, NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome