HAX1 Antikörper (Middle Region)
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- Target Alle HAX1 Antikörper anzeigen
- HAX1 (HCLS1 Associated Protein X-1 (HAX1))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HAX1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- LPGPESETPG ERLREGQTLR DSMLKYPDSH QPRIFGGVLE SDARSESPQP
- Homologie
- Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rat: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against HAX1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human HAX1
- Top Product
- Discover our top product HAX1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 279 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HAX1 (HCLS1 Associated Protein X-1 (HAX1))
- Andere Bezeichnung
- HAX1 (HAX1 Produkte)
- Synonyme
- HAX1 antikoerper, hax1 antikoerper, HCLSBP1 antikoerper, HS1BP1 antikoerper, SCN3 antikoerper, HAX-1 antikoerper, Hs1bp1 antikoerper, HSP1BP-1 antikoerper, SIG-111 antikoerper, Silg111 antikoerper, mHAX-1s antikoerper, HCLS1 associated protein X-1 antikoerper, HCLS1 associated X-1 antikoerper, HAX1 antikoerper, hax1 antikoerper, Hax1 antikoerper
- Hintergrund
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HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HCLSBP1, HS1BP1, SCN3
Protein Interaction Partner: ERLIN2, UBC, BIRC3, CEP250, TUBGCP2, TUBGCP3, MAPK10, HIPK1, DYRK4, ZNF420, POLR1D, ZNRD1, RBX1, STAT5B, RPA1, PPP3CC, CFTR, EWSR1, SHC1, HTRA2, NEDD4L, CUL3, CUL4A, PIDD1, SVIL, EBNA-LP, AMFR, HNF4G, AKAP10, TUBB4A, ABCC4, MATN4, EIF3D, RGS1, HSP90AB1, H
Protein Size: 279 - Molekulargewicht
- 31 kDa
- Gen-ID
- 10456
- NCBI Accession
- NM_006118, NP_006109
- UniProt
- O00165
- Pathways
- Regulation of Actin Filament Polymerization
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