Endonuclease G Antikörper (Middle Region)

Produktnummer ABIN2784751

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Endonuclease G Antikörper wird verwendet zum Nachweis von Endonuclease G in Proben von Human, Ratte, Maus, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio) und Rind (Kuh). Er wurde validiert für WB.

Kurzübersicht für Endonuclease G Antikörper (Middle Region) (ABIN2784751)

Target: Endonuclease G (ENDOG)

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endonuclease G Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Endonuclease G Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ENDOG Antibody - middle region

Sequenz: YVMPNAPVDE AIPLERFLVP IESIERASGL LFVPNILARA GSLKAITAGS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ENDOG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ENDOG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52054-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Endonuclease G Antikörper (ABIN2784751)

Guha, Bandyopadhyaya, Polumuri, Chumsri, Gade, Kalvakolanu, Ahmed et al.: "Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic ..." in: Breast cancer research and treatment, Vol. 145, Issue 1, pp. 5-22, (2014) (PubMed).

Details zu Endonuclease G

Target: Endonuclease G (ENDOG)

Andere Bezeichnung: ENDOG

Hintergrund:

Background Information: ENDOG cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, ENDOG also has ribonuclease (RNase) and RNase H activities. ENDOG is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.

Gene Name: Endonuclease G

Alternative Symbols: FLJ27463

Protein Name: Endonuclease G, mitochondrial

Molekulargewicht: 28kDa

Gen-ID: 2021

NCBI Accession: NP_004426

UniProt: Q14249

Pathways: Apoptose