PAXIP1 Antikörper (N-Term)

Produktnummer ABIN2784556

Der Kaninchen Polyklonal anti-PAXIP1 Antikörper wird verwendet zum Nachweis von PAXIP1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für PAXIP1 Antikörper (N-Term) (ABIN2784556)

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAXIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PAXIP1 Antikörper

Bindungsspezifität: N-Term

Sequenz: MFDDSSDSSP EKQERNLNWT PAEVPQLAAA KRRLPQGKEP GLINLCANVP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PAXIP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PAXIP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 697 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PAXIP1

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Andere Bezeichnung: PAXIP1

Hintergrund: PAXIP1 functions as a key component of the DNA damage response, and phosphoserine or phosphothreonine-specific binding modules. PAXIP1 recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. It may play a role in PAX2-dependent transcriptional regulation. PAXIP1 plays a role in early development, most probably in cell proliferation.
Alias Symbols: PTIP, TNRC2, CAGF28, CAGF29, PACIP1, PAXIP1L, FLJ41049
Protein Interaction Partner: MAPRE2, POM121, NXT1, PPARG, XAGE1E, SMAD2, SPATA18, COMTD1, BTBD16, DIS3L, LACTB, HNRNPLL, ZNF251, ZNF622, BTBD6, C7orf50, FAM175A, TMEM120A, FAHD1, TM2D3, ATHL1, CENPU, DYNC2H1, BRCC3, KRI1, ANAPC1, NOM1, POLR1E, NCAPG, AASDHPPT, RBM25, CATSPERG, WDR48,
Protein Size: 697

Molekulargewicht: 74 kDa

Gen-ID: 22976

NCBI Accession: NM_007349

UniProt: Q6ZW49

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response