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PAXIP1 Antikörper (AA 613-812) (FITC)

PAXIP1 Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7162704
  • Target Alle PAXIP1 Antikörper anzeigen
    PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))
    Bindungsspezifität
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 613-812
    Reaktivität
    • 21
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 17
    • 4
    Kaninchen
    Klonalität
    • 19
    • 2
    Polyklonal
    Konjugat
    • 16
    • 2
    • 2
    • 1
    Dieser PAXIP1 Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human PAX-interacting protein 1 protein (613-812AA)
    Isotyp
    IgG
    Top Product
    Discover our top product PAXIP1 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))
    Andere Bezeichnung
    PAXIP1 (PAXIP1 Produkte)
    Synonyme
    CAGF29 antikoerper, PACIP1 antikoerper, PAXIP1L antikoerper, PTIP antikoerper, TNRC2 antikoerper, wu:fa04b06 antikoerper, zgc:92593 antikoerper, cagf28 antikoerper, cagf29 antikoerper, k14 antikoerper, pacip1 antikoerper, paxip1l antikoerper, ptip antikoerper, tnrc2 antikoerper, D5Ertd149e antikoerper, PAX interacting protein 1 antikoerper, PAX interacting (with transcription-activation domain) protein 1 antikoerper, PAX interacting protein 1 L homeolog antikoerper, PAXIP1 antikoerper, paxip1 antikoerper, paxip1.L antikoerper, Paxip1 antikoerper
    Hintergrund

    Background: Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at \'Ser-25\'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage, the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at \'Lys-4\' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, this function appears to involve the recruitment of MLL-containing HMT complexes.

    Aliases: CAGF 28 antibody, CAGF 29 antibody, CAGF28 antibody, CAGF29 antibody, FLJ41049 antibody, PACIP 1 antibody, PACIP1 antibody, PAX interacting (with transcription activation domain) protein 1 antibody, PAX interacting protein 1 antibody, PAX transactivation activation domain-interacting protein antibody, PAX transcription activation domain interacting protein 1 like antibody, PAX-interacting protein 1 antibody, PAXI1_HUMAN antibody, PAXIP 1 antibody, PAXIP 1L antibody, paxip1 antibody, PAXIP1 protein antibody, PAXIP1L antibody, Protein encoded by CAG trinucleotide repeats antibody, PTIP antibody, TNRC 2 antibody, TNRC2 antibody

    UniProt
    Q6ZW49
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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