FZR1 Antikörper (N-Term)

Produktnummer ABIN2784494

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-FZR1 Antikörper wird verwendet zum Nachweis von FZR1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für FZR1 Antikörper (N-Term) (ABIN2784494)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FZR1 Antikörper

Bindungsspezifität: N-Term

Sequenz: SSPVSSPSKH GDRFIPSRAG ANWSVNFHRI NENEKSPSQN RKAKDATSDN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FZR1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 493 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FZR1 Antikörper (ABIN2784494)

Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR1

Hintergrund: FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB
Protein Size: 493

Molekulargewicht: 55 kDa

Gen-ID: 51343

NCBI Accession: NM_016263, NP_057347

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA