POLR2H Antikörper (N-Term)

Produktnummer ABIN2783467

Produktdetails anti-POLR2H Antikörper

Target: POLR2H (Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLR2H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DLGDKFRLVI ASTLYEDGTL DDGEYNPTDD RPSRADQFEY VMYGKVYRIE

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against POLR2H. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POLR2H

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 150 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-POLR2H Antikörper (ABIN2783467)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu POLR2H

Target: POLR2H (Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H))

Andere Bezeichnung: POLR2H (POLR2H Produkte)

Synonyme: RPABC3 antikoerper, RPB17 antikoerper, RPB8 antikoerper, POLR2H antikoerper, RGD1561203 antikoerper, rpb8 antikoerper, rpb17 antikoerper, hsrpb8 antikoerper, rpabc3 antikoerper, zgc:110289 antikoerper, RNA polymerase II subunit H antikoerper, polymerase (RNA) II (DNA directed) polypeptide H antikoerper, polymerase (RNA) II subunit H L homeolog antikoerper, polymerase (RNA) II subunit H antikoerper, info polymerase (RNA) II (DNA directed) polypeptide H antikoerper, POLR2H antikoerper, Polr2h antikoerper, polr2h.L antikoerper, polr2h antikoerper

Hintergrund: POLR2H is one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-400 AU142999.1 1-400 401-907 BI772069.1 287-793 908-1792 BC008348.1 928-1812 1793-3185 AC099344.4 111461-112853 c
Alias Symbols: RPABC3, RPB17, RPB8, hsRPB8
Protein Interaction Partner: TCEB3, SRC, PSMB9, ESR1, CEP57, RNF2, SNRNP200, SART3, POLR2E, DNMT3B, DNMT3A, BAG3, POLR2C, MED19, METTL18, MED26, UBC, POLR3D, POLR3H, POLR3B, POLR1A, POLR3A, POLR1C, NEDD8, Atf7ip, SUMO2, INTS10, POLR2D, POLR2A, BRCA1, BARD1, INTS5, INTS3, INTS6, INTS1
Protein Size: 150

Molekulargewicht: 17 kDa

Gen-ID: 5437

NCBI Accession: NM_006232, NP_006223

UniProt: P52434

Pathways: Regulatorische RNA Pathways