GADD45B Antikörper (Middle Region)

Produktnummer ABIN2783334

Zitiert in 5+ Publikationen. Der Kaninchen Polyklonal anti-GADD45B Antikörper (ABIN2783334) detektiert spezifisch GADD45B in IHC und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Schwein.

Kurzübersicht für GADD45B Antikörper (Middle Region) (ABIN2783334)

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GADD45B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-GADD45B Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: GADD45B Antibody - middle region

Sequenz: FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GADD45B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GADD45B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48346-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GADD45B Antikörper (ABIN2783334)

Ursini, Cavalleri, Fazio, Angrisano, Iacovelli, Porcelli, Maddalena, Punzi, Mancini, Gelao, Romano, Masellis, Calabrese, Rampino, Taurisano, Di Giorgio, Keller, Tarantini, Sinibaldi, Quarto et al.: "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..." in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016) (PubMed).

Gavin, Kusumo, Zhang, Guidotti, Pandey: "Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors." in: Alcoholism, clinical and experimental research, Vol. 40, Issue 2, pp. 263-72, (2016) (PubMed).

Matrisciano, Dong, Gavin, Nicoletti, Guidotti: "Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain." in: Molecular pharmacology, Vol. 80, Issue 1, pp. 174-82, (2011) (PubMed).

Gavin, Sharma, Chase, Matrisciano, Dong, Guidotti: "Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 2, pp. 531-42, (2011) (PubMed).

Tornatore, Marasco, Dathan, Vitale, Benedetti, Papa, Franzoso, Ruvo, Monti: "Gadd45 beta forms a homodimeric complex that binds tightly to MKK7." in: Journal of molecular biology, Vol. 378, Issue 1, pp. 97-111, (2008) (PubMed).

Details zu GADD45B

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Andere Bezeichnung: GADD45B

Hintergrund:

Background Information: The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Growth arrest and DNA-damage-inducible, beta

Alternative Symbols: MYD118, GADD45BETA

Protein Name: Growth arrest and DNA damage-inducible protein GADD45 beta

Molekulargewicht: 18kDa

Gen-ID: 4616

NCBI Accession: NP_056490

UniProt: O75293

Pathways: Zellzyklus