CAMLG Antikörper (N-Term)

Produktnummer ABIN2783272

Dieses Anti-CAMLG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CAMLG in WB. Geeignet für Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein und Kaninchen.

Kurzübersicht für CAMLG Antikörper (N-Term) (ABIN2783272)

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Reaktivität: Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMLG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CAMLG Antikörper

Bindungsspezifität: N-Term

Sequenz: LLMNSEQRIN RIMGFHRPGS GAEEESQTKS KQQDSDKLNS LSVPSVSKRV

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against CAMLG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAMLG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 296 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CAMLG

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Andere Bezeichnung: CAMLG

Hintergrund: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Alias Symbols: CAML, MGC163197
Protein Interaction Partner: KCNA2, TMUB1, TNFRSF13B, UBC, RNF122, PKHD1, EGFR, PPIB, IER3,
Protein Size: 296

Molekulargewicht: 33 kDa

Gen-ID: 819

NCBI Accession: NM_001745, NP_001736

UniProt: P49069

Pathways: EGFR Signaling Pathway