PLEKHO1 Antikörper (N-Term)

Produktnummer ABIN2783148

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PLEKHO1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Rind (Kuh) und Schwein.

Kurzübersicht für PLEKHO1 Antikörper (N-Term) (ABIN2783148)

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Reaktivität: Human, Ratte, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLEKHO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLEKHO1 Antikörper

Bindungsspezifität: N-Term

Sequenz: MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG

Homologie: Cow: 86%, Human: 100%, Pig: 86%, Rat: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against PLEKHO1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PLEKHO1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 409 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PLEKHO1

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Andere Bezeichnung: PLEKHO1

Hintergrund: PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Alias Symbols: CKIP-1, OC120, RP11-458I7.3
Protein Interaction Partner: PLEKHO1, AKT3, AKT2, AKT1, UBC, GSK3B, TRAF6, Arpc1a, Stub1, Rps3a1, SMURF1, PSMC5, USP7, C10orf88, RPS20, IFI35, DNAJB1, FLNB, CSNK2A1, SMAD5, JUND, JUN, CASP3,
Protein Size: 409

Molekulargewicht: 46 kDa

Gen-ID: 51177

NCBI Accession: NM_016274, NP_057358

UniProt: Q53GL0