GP6 Antikörper (Middle Region)
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- Target Alle GP6 Antikörper anzeigen
- GP6 (Glycoprotein VI (Platelet) (GP6))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GP6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY
- Homologie
- Human: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against GP6. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human GP6
- Top Product
- Discover our top product GP6 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 339 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- GP6 (Glycoprotein VI (Platelet) (GP6))
- Andere Bezeichnung
- GP6 (GP6 Produkte)
- Synonyme
- BDPLT11 antikoerper, GPIV antikoerper, GPVI antikoerper, 9830166G18Rik antikoerper, Gm469 antikoerper, Gpvi antikoerper, GP6 antikoerper, glycoprotein VI platelet antikoerper, glycoprotein 6 (platelet) antikoerper, glycoprotein VI antikoerper, platelet glycoprotein VI antikoerper, GP6 antikoerper, Gp6 antikoerper, LOC103346235 antikoerper
- Hintergrund
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Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].
Alias Symbols: GPIV, GPVI, MGC138168, BDPLT11
Protein Interaction Partner: NCF1, TRAF4, TGFB1I1, LYN, PTK2B, CALM1, FCER1G, YES1, FCGR2A, FCGR3A, FYN, CRP,
Protein Size: 339 - Molekulargewicht
- 37 kDa
- Gen-ID
- 51206
- NCBI Accession
- NM_016363, NP_057447
- UniProt
- Q9HCN6
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