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GP6 Antikörper (Middle Region)

GP6 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2782886
  • Target Alle GP6 Antikörper anzeigen
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Bindungsspezifität
    • 15
    • 13
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 48
    • 19
    • 19
    Human
    Wirt
    • 47
    • 1
    Kaninchen
    Klonalität
    • 46
    • 1
    • 1
    Polyklonal
    Konjugat
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GP6 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 18
    • 13
    • 13
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY
    Homologie
    Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against GP6. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human GP6
    Top Product
    Discover our top product GP6 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 339 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Andere Bezeichnung
    GP6 (GP6 Produkte)
    Synonyme
    BDPLT11 antikoerper, GPIV antikoerper, GPVI antikoerper, 9830166G18Rik antikoerper, Gm469 antikoerper, Gpvi antikoerper, GP6 antikoerper, glycoprotein VI platelet antikoerper, glycoprotein 6 (platelet) antikoerper, glycoprotein VI antikoerper, platelet glycoprotein VI antikoerper, GP6 antikoerper, Gp6 antikoerper, LOC103346235 antikoerper
    Hintergrund
    Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].
    Alias Symbols: GPIV, GPVI, MGC138168, BDPLT11
    Protein Interaction Partner: NCF1, TRAF4, TGFB1I1, LYN, PTK2B, CALM1, FCER1G, YES1, FCGR2A, FCGR3A, FYN, CRP,
    Protein Size: 339
    Molekulargewicht
    37 kDa
    Gen-ID
    51206
    NCBI Accession
    NM_016363, NP_057447
    UniProt
    Q9HCN6
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