ERVW-1 Antikörper (N-Term)

Produktnummer ABIN502797

Produktdetails anti-ERVW-1 Antikörper

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Bindungsspezifität: N-Term

Reaktivität: Human, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERVW-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TQTGMSDGGG VQDQAREKHV KEVISQLTRV HGTSSPYKGL DLSKLHETLR

Homologie: Human: 100%, Rabbit: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against ERVWE1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ERVWE1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 538 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ERVW-1

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Andere Bezeichnung: ERVWE1 (ERVW-1 Produkte)

Hintergrund: ERVWE1 or syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Env-W, HERV-7q, HERV-W, HERV-W-ENV, HERVW, env, syncytin, ENV, ENVW, ERVWE1, HERV7Q, HERVWENV
Protein Interaction Partner: SLC1A4, SLC1A5,
Protein Size: 538

Molekulargewicht: 24 kDa

Gen-ID: 30816

NCBI Accession: NM_014590, NP_055405

UniProt: Q9UQF0