Cadherin 12 Antikörper (Middle Region)

Produktnummer ABIN2782614

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cadherin 12 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Hund, Meerschweinchen, Kaninchen, Rind (Kuh), Pferd und Zebrafisch (Danio rerio).

Kurzübersicht für Cadherin 12 Antikörper (Middle Region) (ABIN2782614)

Target: Cadherin 12

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cadherin 12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cadherin 12 Antikörper

Bindungsspezifität: Middle Region

Sequenz: DTQEGVIKLK KPLDFETKKA YTFKVEASNL HLDHRFHSAG PFKDTATVKI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CDH12. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDH12

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 794 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Cadherin 12

Target: Cadherin 12

Andere Bezeichnung: CDH12

Hintergrund: CDH12 belongs to the protocadherin protein family, a subfamily of the cadherin superfamily. It consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Alias Symbols: CDHB, FLJ34857
Protein Interaction Partner: CDH7, CDH18,
Protein Size: 794

Molekulargewicht: 82 kDa

Gen-ID: 1010

NCBI Accession: NM_004061, NP_004052

UniProt: P55289