Oncostatin M Receptor Antikörper (Middle Region)

Produktnummer ABIN2782613

Produktdetails anti-Oncostatin M Receptor Antikörper

Target: Oncostatin M Receptor (OSMR)

Bindungsspezifität: Middle Region

Reaktivität: Human, Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oncostatin M Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LLEKKTGYSQ ELAPSDNPHV LVDTLTSHSF TLSWKDYSTE SQPGFIQGYH

Homologie: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against OSMR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human OSMR

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 979 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Andere Bezeichnung: OSMR (OSMR Produkte)

Synonyme: OSMRB antikoerper, PLCA1 antikoerper, oncostatin M receptor antikoerper, OSMR antikoerper, Osmr antikoerper

Hintergrund: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC150626, MGC150627, MGC75127, OSMRB, PLCA1
Protein Interaction Partner: UBC, CUL5, GAPDH, IL6ST, OSM, JAK2, JAK1, ERBB2,
Protein Size: 979

Molekulargewicht: 110 kDa

Gen-ID: 9180

NCBI Accession: NM_003999, NP_003990

UniProt: Q99650

Pathways: JAK-STAT Signalweg, Growth Factor Binding