Oncostatin M Receptor Antikörper (N-Term)

Produktnummer ABIN2782612

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Oncostatin M Receptor in WB. Es zeigt Reaktivität gegenüber Proben von Human, Hund und Rind (Kuh).

Kurzübersicht für Oncostatin M Receptor Antikörper (N-Term) (ABIN2782612)

Target: Oncostatin M Receptor (OSMR)

Reaktivität: Human, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oncostatin M Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Oncostatin M Receptor Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: OSMR Antibody - N-terminal region

Sequenz: YQSEVLAERL PLTPVSLKVS TNSTRQSLHL QWTVHNLPYH QELKMVFQIQ

Homologie: Cow: 77%, Dog: 79%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against OSMR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OSMR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8107339

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Andere Bezeichnung: OSMR

Hintergrund:

Targeted Subunit: beta

Background Information: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Oncostatin M receptor

Alternative Symbols: OSMRB, PLCA1, IL-31RB, OSMRbeta, IL-31R-beta

Protein Name: Oncostatin-M-specific receptor subunit beta

Molekulargewicht: 111 kDa

Gen-ID: 9180

NCBI Accession: NP_003990

UniProt: Q99650

Pathways: JAK-STAT Signalweg, Growth Factor Binding