MELK Antikörper (N-Term)

Produktnummer ABIN2782539

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MELK in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Pferd, Meerschweinchen, Hund, Kaninchen und Schwein.

Kurzübersicht für MELK Antikörper (N-Term) (ABIN2782539)

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Meerschweinchen, Hund, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MELK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MELK Antikörper

Bindungsspezifität: N-Term

Sequenz: GFAKVKLACH VLTGEMVAIK IMDKNALGSD LPRVKTEIDA LKSLRHQHIC

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against Melk. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Melk

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MELK

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Andere Bezeichnung: Melk

Hintergrund: Melk is a Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Melk Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. It Plays a key role in cell proliferation. It is required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. It's also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus and may also play a role in primitive hematopoiesis.
Alias Symbols: AI327312, MPK38, mKIAA0175
Protein Interaction Partner: Txn1, ZNF622, UBC, TXN, TP53, MAP3K5, MDM2, SMAD7, SMAD3,
Protein Size: 643

Molekulargewicht: 70 kDa

Gen-ID: 17279

NCBI Accession: NM_010790, NP_034920

UniProt: Q61846