CENPA Antikörper (Middle Region)

Produktnummer ABIN502692

Dieses Anti-CENPA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CENPA in WB. Geeignet für Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio) und Ziege.

Kurzübersicht für CENPA Antikörper (Middle Region) (ABIN502692)

Target: CENPA (Centromere Protein A (CENPA))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CENPA Antikörper

Bindungsspezifität: Middle Region

Sequenz: ALQEAAEAFL VHLFEDAYLL TLHAGRVTLF PKDVQLARRI RGLEEGLG

Homologie: Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against CENPA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CENPA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 140 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CENPA

Target: CENPA (Centromere Protein A (CENPA))

Andere Bezeichnung: CENPA

Hintergrund: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA is a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: CenH3, CENP-A
Protein Interaction Partner: HIST1H4A, HIST1H2AB, H3F3A, HIST1H2BB, DIAPH3, DIAPH1, NPM1, HIST1H1A, H2AFZ, H2AFX, CENPC, CENPB, HIST3H2BB, HIST4H4, CENPT, CENPU, CENPM, CENPH, CENPN, HJURP, SUPT16H, H2AFY, AURKB, HIST1H3E, HIST2H2AC, SSRP1, RUVBL1, XRCC5, PRKDC, HNRNPU, EIF4A1, DDX5,
Protein Size: 140

Molekulargewicht: 16 kDa

Gen-ID: 1058

NCBI Accession: NM_001809, NP_001800

UniProt: P49450

Pathways: Chromatin Binding, Maintenance of Protein Location