Retinoid X Receptor gamma Antikörper (N-Term)

Produktnummer ABIN2782291

Produktdetails anti-Retinoid X Receptor gamma Antikörper

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoid X Receptor gamma Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RXRG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RXRG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 463 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Retinoid X Receptor gamma Antikörper (ABIN2782291)

Bungard, McGivan: "Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers." in: Archives of biochemistry and biophysics, Vol. 443, Issue 1-2, pp. 53-9, (2005) (PubMed).

Details zu Retinoid X Receptor gamma

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Andere Bezeichnung: RXRG (RXRG Produkte)

Hintergrund: RXRG encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXRG is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: NR2B3, RXRC
Protein Interaction Partner: NR1H3, NR1H2, RARB, RARA, MPPED2, UBC, CUL1, DCK, NR1H4, NCOR2, NR1I2, VDR, THRB, RARG, PPARD, MAP4, CAMK2B, CEBPZ, HOXD4, AJUBA, RPAP2, LRSAM1, PNO1, CHGB, THRA, NCOA6, PPARG, SRF, CREBBP, PPARA, NR4A1, Nr0b2, ITGB3BP,
Protein Size: 463

Molekulargewicht: 51 kDa

Gen-ID: 6258

NCBI Accession: NM_006917, NP_008848

UniProt: P48443

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway