GALNT4 Antikörper (C-Term)

Produktnummer ABIN2782249

Dieser Anti-GALNT4 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von GALNT4 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein und Zebrafisch (Danio rerio).

Kurzübersicht für GALNT4 Antikörper (C-Term) (ABIN2782249)

Target: GALNT4 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GALNT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GALNT4 Antikörper

Bindungsspezifität: C-Term

Sequenz: ANLSLFGCHG QGGNQFFEYT SNKEIRFNSV TELCAEVPEQ KNYVGMQNCP

Homologie: Cow: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GALNT4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GALNT4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 578 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GALNT4

Target: GALNT4 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4))

Andere Bezeichnung: GALNT4

Hintergrund: GALNT4 catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 Molecule. The coding region of this gene is contained within a single exon.
Alias Symbols: GALNAC-T4, GalNAcT4, GALNACT4
Protein Interaction Partner: ELAVL1, SELPLG, MUC1,
Protein Size: 578

Molekulargewicht: 67 kDa

Gen-ID: 8693

NCBI Accession: NM_003774, NP_003765

UniProt: Q8N4A0