ICAM5 Antikörper (N-Term)

Produktnummer ABIN2782226

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ICAM5 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für ICAM5 Antikörper (N-Term) (ABIN2782226)

Target: ICAM5 (Intercellular Adhesion Molecule 5 (ICAM5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ICAM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ICAM5 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ICAM5 Antibody - N-terminal region

Sequenz: RRNGTQRGLR WLARQLVDIR EPETQPVCFF RCARRTLQAR GLIRTFQRPD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ICAM5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ICAM5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45452-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ICAM5 Antikörper (ABIN2782226)

Tian, Lappalainen, Autero, Hänninen, Rauvala, Gahmberg: "Shedded neuronal ICAM-5 suppresses T-cell activation." in: Blood, Vol. 111, Issue 7, pp. 3615-25, (2008) (PubMed).

Details zu ICAM5

Target: ICAM5 (Intercellular Adhesion Molecule 5 (ICAM5))

Andere Bezeichnung: ICAM5

Hintergrund:

Background Information: ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Intercellular adhesion molecule 5, telencephalin

Alternative Symbols: TLN, TLCN

Protein Name: Intercellular adhesion molecule 5

Molekulargewicht: 95kDa

Gen-ID: 7087

NCBI Accession: NP_003250

UniProt: Q9UMF0

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location