TAPBP Antikörper (C-Term)

Produktnummer ABIN2782218

Der Kaninchen Polyklonal Anti-TAPBP-Antikörper wurde für WB und IHC validiert. Er ist geeignet, TAPBP in Proben von Human, Schaf, Rind (Kuh) und Schwein zu detektieren.

Kurzübersicht für TAPBP Antikörper (C-Term) (ABIN2782218)

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Reaktivität: Human, Schaf, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAPBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TAPBP Antikörper

Bindungsspezifität: C-Term

Sequenz: GEAPPELLCL VSHFYPSGGL EVEWELRGGP GGRSQKAEGQ RWLSALRHHS

Homologie: Cow: 86%, Human: 100%, Pig: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against TAPBP. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TAPBP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 448 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TAPBP

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Andere Bezeichnung: TAPBP

Hintergrund: TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum.This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Alias Symbols: NGS17, TAPA, TPN, TPSN
Protein Interaction Partner: UBC, PDIA3, Tap2, ELAVL1, US3, TAP1, B2M, COPG1, COPG2, COPB1, HLA-C, HLA-A, CALR,
Protein Size: 448

Molekulargewicht: 46 kDa

Gen-ID: 6892

NCBI Accession: NM_003190, NP_003181

UniProt: O15533