HBEGF Antikörper (N-Term)

Produktnummer ABIN2782149

Produktdetails anti-HBEGF Antikörper

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HBEGF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FLAAVLSALV TGESLERLRR GLAAGTSNPD PPTVSTDQLL PLGGGRDRKV

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HBEGF. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HBEGF

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HBEGF

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Andere Bezeichnung: HBEGF (HBEGF Produkte)

Synonyme: hbegf antikoerper, zgc:165443 antikoerper, HBEGF antikoerper, zgc:175091 antikoerper, DTR antikoerper, DTS antikoerper, DTSF antikoerper, HEGFL antikoerper, Dtr antikoerper, GFHB antikoerper, Hb-egf antikoerper, Hegfl antikoerper, AW047313 antikoerper, Dts antikoerper, HB-EGF antikoerper, heparin-binding EGF-like growth factor b antikoerper, heparin binding EGF like growth factor antikoerper, Heparin-binding EGF-like growth factor antikoerper, heparin-binding EGF-like growth factor a antikoerper, heparin-binding EGF-like growth factor antikoerper, hbegfb antikoerper, HBEGF antikoerper, hbegf antikoerper, hbegfa antikoerper, Hbegf antikoerper

Hintergrund: HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
Alias Symbols: DTR, DTS, DTSF, HEGFL
Protein Interaction Partner: Bag1, BCL6, ZBTB16, CD82, NRD1, LTBP3, ERBB4, MMP7, CD9, FBLN1, EGFR, HBEGF, CD44,
Protein Size: 208

Molekulargewicht: 22 kDa

Gen-ID: 1839

NCBI Accession: NM_001945, NP_001936

UniProt: Q99075

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung