ITM2C Antikörper (Middle Region)
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- Target Alle ITM2C Antikörper anzeigen
- ITM2C (Integral Membrane Protein 2C (ITM2C))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schaf, Kaninchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ITM2C Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product ITM2C Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 267 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ITM2C (Integral Membrane Protein 2C (ITM2C))
- Andere Bezeichnung
- ITM2C (ITM2C Produkte)
- Synonyme
- 3110038L02Rik antikoerper, BRI3 antikoerper, Bricd2c antikoerper, E25 antikoerper, E25C antikoerper, ITM3 antikoerper, BRICD2C antikoerper, fj35c02 antikoerper, itm2c antikoerper, wu:fj35c02 antikoerper, zgc:66349 antikoerper, wu:fj52a04 antikoerper, zgc:92783 antikoerper, integral membrane protein 2C antikoerper, integral membrane protein 2Cb antikoerper, integral membrane protein 2Ca antikoerper, Itm2c antikoerper, ITM2C antikoerper, itm2cb antikoerper, itm2ca antikoerper
- Hintergrund
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ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Alias Symbols: BRI3, BRICD2C, E25, E25C, ITM3
Protein Interaction Partner: UBC, Dlg4, RYK, BACE1, RNF7, STT3A, MTNR1B, FURIN,
Protein Size: 267 - Molekulargewicht
- 30 kDa
- Gen-ID
- 81618
- NCBI Accession
- NM_030926, NP_112188
- UniProt
- Q9NQX7
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