SRD5A2 Antikörper (N-Term)

Produktnummer ABIN2781789

Produktdetails anti-SRD5A2 Antikörper

Target: SRD5A2 (Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Hund, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRD5A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KHTESLKPAA TRLPARAAWF LQELPSFAVP AGILARQPLS LFGPPGTVLL

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 93%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SRD5A2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SRD5A2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 254 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SRD5A2 Antikörper (ABIN2781789)

Bertin, Dury, Ouellet, Pelletier, Labrie: "Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction." in: The journal of sexual medicine, Vol. 11, Issue 8, pp. 1949-61, (2014) (PubMed).

Details zu SRD5A2

Target: SRD5A2 (Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2))

Andere Bezeichnung: SRD5A2 (SRD5A2 Produkte)

Synonyme: S5AR 2 antikoerper, 5ART2 antikoerper, SRD5alpha2 antikoerper, SRD5A2 antikoerper, Srd5a2 antikoerper, CH73-233A22.6 antikoerper, wu:fk70d02 antikoerper, zgc:109942 antikoerper, zgc:112208 antikoerper, zgc:112455 antikoerper, steroid 5 alpha-reductase 2 antikoerper, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antikoerper, 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antikoerper, steroid-5-alpha-reductase, alpha polypeptide 2a antikoerper, steroid-5-alpha-reductase, alpha polypeptide 2b antikoerper, SRD5A2 antikoerper, Srd5a2 antikoerper, srd5a2 antikoerper, LOC100125532 antikoerper, srd5a2a antikoerper, srd5a2b antikoerper

Hintergrund: This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
Alias Symbols: MGC138457
Protein Size: 254

Molekulargewicht: 28 kDa

Gen-ID: 6716

NCBI Accession: NM_000348, NP_000339

UniProt: P31213

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis